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KMID : 0811720050090000060
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Korean Journal of Physiology & Pharmacology
2005 Volume.9 No. 0 p.60 ~ p.0
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Modulation of Neuronal Activity by EGCG
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Jang Su-Jeong
Park Jin
Jang Myung-Joo
Jeong Han-Seong
Park Jong-Seong
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Abstract
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This study aims to investigate whether (-)-epigallocatechin-3-gallate (EGCG) affects neuronal activity of acutely isolated rat medial vestibular nuclear neurons in whole-cell configuration patch-clamp experiments. EGCG (0.5 and 1μM) lowered the spontaneous firing rate and hyperpolarized the membrane potential of medial vestibular nuclear neurons. However, it did not change the amplitude of afterhyperpolarization or the spike width of the action potential. A second application of EGCG with the same concentration elicited lesser responses. These results suggest that EGCG decreases neuronal activity by affecting potassium currents which are responsible for membrane potentials.
Source: Korean Journal of Physiology & Pharmacology.2005 Oct;9(Suppl I):S85-S85
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KEYWORD
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EGCG, Medial vestibular nucleus, Action potential, Potassium current
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